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Direct Answer Bercot treats differences as doctrinally significant when they affect Christ-centered teaching—especially messianic prophecy, worship of Christ, and the incarnation—rather than small wording changes. He argues these examples suggest God providentially guarded the form of the Old Testament that the apostles and Jesus actually used, namely the Septuagint.

Support from Transcript:

• He says most verses read “almost identically,” but “some of these differences aren’t quite significant,” and yet “some of these differences are…quite significant,” so it’s “not some light matter.”
• Deut 32:43: the Masoretic lacks the line entirely, but the Septuagint includes, “let all the angels of God worship him,” which Hebrews 1:6 uses—so the difference impacts worship and Christology.
• Ps 40:6 / Heb 10:5: Masoretic says “Mine ears hast thou opened,” but the Septuagint (and Hebrews) says, “a body hast thou prepared for me.” Bercot calls this omission important because “the significance of the incarnation is wrapped up” in that wording.
• Isa 7:14: Septuagint says “virgin,” while the Masoretic reads “young woman.” He calls this “perhaps the single most significant Old Testament prophecy,” tying it to the “central and essential teaching” of the virgin birth.
• He argues God would not inspire apostles to quote “in error,” implying providential preservation.